Discussion:
corona help
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Automatic
2020-01-28 04:21:20 UTC
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https://news.bloomberglaw.com/health-law-and-business/coronavirus-vaccine-candidate-eyed-for-human-trials-by-april
Automatic
2020-01-28 04:23:13 UTC
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Post by Automatic
https://news.bloomberglaw.com/health-law-and-business/coronavirus-vaccine-candidate-eyed-for-human-trials-by-april
"to help patients who are infected. One such antiviral is remdesivir, which is an investigational agent Gilead Sciences Inc., has been studying to treat the Ebola virus.

Mark R. Denison, who’s been working on antivirals for SARS and MERS and animal coronaviruses, said in an email that remdesivir stops the virus by blocking an enzyme it needs to replicate. Viruses have trouble developing resistance to remdesivir, resulting in a weaker virus, he said.

The replication protein in the latest coronavirus outbreak “is highly similar to that of SARS-[coronavirus] so we predict it would be inhibited by [remdesivir],” Denison, director of infectious disease at Vanderbilt University medical school, said in an email."
Automatic
2020-01-28 04:29:20 UTC
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Post by Automatic
https://news.bloomberglaw.com/health-law-and-business/coronavirus-vaccine-candidate-eyed-for-human-trials-by-april
"to help patients who are infected. One such antiviral is remdesivir, which is an investigational agent Gilead Sciences Inc., has been studying to treat the Ebola virus.
Mark R. Denison, who’s been working on antivirals for SARS and MERS and animal coronaviruses, said in an email that remdesivir stops the virus by blocking an enzyme it needs to replicate. Viruses have trouble developing resistance to remdesivir, resulting in a weaker virus, he said.
The replication protein in the latest coronavirus outbreak “is highly similar to that of SARS-[coronavirus] so we predict it would be inhibited by [remdesivir],” Denison, director of infectious disease at Vanderbilt University medical school, said in an email."
https://www.ncbi.nlm.nih.gov/m/pubmed/31924756/?i=1&from=GS-5734%20OR%20Remdesivir
Automatic
2020-01-28 04:30:45 UTC
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Post by Automatic
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https://news.bloomberglaw.com/health-law-and-business/coronavirus-vaccine-candidate-eyed-for-human-trials-by-april
"to help patients who are infected. One such antiviral is remdesivir, which is an investigational agent Gilead Sciences Inc., has been studying to treat the Ebola virus.
Mark R. Denison, who’s been working on antivirals for SARS and MERS and animal coronaviruses, said in an email that remdesivir stops the virus by blocking an enzyme it needs to replicate. Viruses have trouble developing resistance to remdesivir, resulting in a weaker virus, he said.
The replication protein in the latest coronavirus outbreak “is highly similar to that of SARS-[coronavirus] so we predict it would be inhibited by [remdesivir],” Denison, director of infectious disease at Vanderbilt University medical school, said in an email."
https://www.ncbi.nlm.nih.gov/m/pubmed/31924756/?i=1&from=GS-5734%20OR%20Remdesivir
RDV improve pulmonary function and reduce lung viral loads and severe lung pathology.
Automatic
2020-01-28 04:38:33 UTC
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Post by Automatic
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Post by Automatic
https://news.bloomberglaw.com/health-law-and-business/coronavirus-vaccine-candidate-eyed-for-human-trials-by-april
"to help patients who are infected. One such antiviral is remdesivir, which is an investigational agent Gilead Sciences Inc., has been studying to treat the Ebola virus.
Mark R. Denison, who’s been working on antivirals for SARS and MERS and animal coronaviruses, said in an email that remdesivir stops the virus by blocking an enzyme it needs to replicate. Viruses have trouble developing resistance to remdesivir, resulting in a weaker virus, he said.
The replication protein in the latest coronavirus outbreak “is highly similar to that of SARS-[coronavirus] so we predict it would be inhibited by [remdesivir],” Denison, director of infectious disease at Vanderbilt University medical school, said in an email."
https://www.ncbi.nlm.nih.gov/m/pubmed/31924756/?i=1&from=GS-5734%20OR%20Remdesivir
RDV improve pulmonary function and reduce lung viral loads and severe lung pathology.
https://www.ncbi.nlm.nih.gov/pubmed/29511076

Together, these studies define the target of GS-5734 activity and demonstrate that resistance is difficult to select, only partial, and impairs fitness and virulence of MHV and SARS-CoV, supporting further development of GS-5734 as a potential effective pan-CoV antiviral.
Automatic
2020-01-28 04:41:17 UTC
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https://news.bloomberglaw.com/health-law-and-business/coronavirus-vaccine-candidate-eyed-for-human-trials-by-april
"to help patients who are infected. One such antiviral is remdesivir, which is an investigational agent Gilead Sciences Inc., has been studying to treat the Ebola virus.
Mark R. Denison, who’s been working on antivirals for SARS and MERS and animal coronaviruses, said in an email that remdesivir stops the virus by blocking an enzyme it needs to replicate. Viruses have trouble developing resistance to remdesivir, resulting in a weaker virus, he said.
The replication protein in the latest coronavirus outbreak “is highly similar to that of SARS-[coronavirus] so we predict it would be inhibited by [remdesivir],” Denison, director of infectious disease at Vanderbilt University medical school, said in an email."
https://www.ncbi.nlm.nih.gov/m/pubmed/31924756/?i=1&from=GS-5734%20OR%20Remdesivir
RDV improve pulmonary function and reduce lung viral loads and severe lung pathology.
https://www.ncbi.nlm.nih.gov/pubmed/29511076
Together, these studies define the target of GS-5734 activity and demonstrate that resistance is difficult to select, only partial, and impairs fitness and virulence of MHV and SARS-CoV, supporting further development of GS-5734 as a potential effective pan-CoV antiviral.
Here, we expand the known efficacy of the nucleotide prodrug remdesivir (GS-5734) to include a group β-2a CoV. Further, GS-5734 potently inhibits CoVs with intact proofreading. Following selection with the GS-5734 parent nucleoside, 2 amino acid substitutions in the nsp12 polymerase at residues that are identical across CoVs provide low-level resistance to GS-5734. The resistance mutations decrease viral fitness of MHV in vitro and attenuate [reduce the force, effect] pathogenesis in a SARS-CoV animal model of infection.
Jack Shit
2020-01-28 04:52:03 UTC
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On Mon, 27 Jan 2020 20:41:17 -0800 (PST), Automatic
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https://news.bloomberglaw.com/health-law-and-business/coronavirus-vaccine-candidate-eyed-for-human-trials-by-april
"to help patients who are infected. One such antiviral is remdesivir, which is an investigational agent Gilead Sciences Inc., has been studying to treat the Ebola virus.
Mark R. Denison, who’s been working on antivirals for SARS and MERS and animal coronaviruses, said in an email that remdesivir stops the virus by blocking an enzyme it needs to replicate. Viruses have trouble developing resistance to remdesivir, resulting in a weaker virus, he said.
The replication protein in the latest coronavirus outbreak “is highly similar to that of SARS-[coronavirus] so we predict it would be inhibited by [remdesivir],” Denison, director of infectious disease at Vanderbilt University medical school, said in an email."
https://www.ncbi.nlm.nih.gov/m/pubmed/31924756/?i=1&from=GS-5734%20OR%20Remdesivir
RDV improve pulmonary function and reduce lung viral loads and severe lung pathology.
https://www.ncbi.nlm.nih.gov/pubmed/29511076
Together, these studies define the target of GS-5734 activity and demonstrate that resistance is difficult to select, only partial, and impairs fitness and virulence of MHV and SARS-CoV, supporting further development of GS-5734 as a potential effective pan-CoV antiviral.
Here, we expand the known efficacy of the nucleotide prodrug remdesivir (GS-5734) to include a group ?-2a CoV. Further, GS-5734 potently inhibits CoVs with intact proofreading. Following selection with the GS-5734 parent nucleoside, 2 amino acid substitutions in the nsp12 polymerase at residues that are identical across CoVs provide low-level resistance to GS-5734. The resistance mutations decrease viral fitness of MHV in vitro and attenuate [reduce the force, effect] pathogenesis in a SARS-CoV animal model of infection.
Boy! If is wasn't for Google people might think you're stupid.
Automatic
2020-01-28 22:29:30 UTC
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Post by Jack Shit
Boy! If is wasn't for Google people might think you're stupid.
this was sold to the american people back in the day as the information superhighway

you seem to bring behavior worse than at a local diner here online and spew it
Jack Shit
2020-01-28 23:06:16 UTC
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On Tue, 28 Jan 2020 14:29:30 -0800 (PST), Automatic
Post by Automatic
Post by Jack Shit
Boy! If is wasn't for Google people might think you're stupid.
this was sold to the american people back in the day as the information superhighway
you seem to bring behavior worse than at a local diner here online and spew it
Put down the bottle and get back to us when you sober up.
Automatic
2020-01-28 23:07:19 UTC
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Post by Jack Shit
On Tue, 28 Jan 2020 14:29:30 -0800 (PST), Automatic
Post by Automatic
Post by Jack Shit
Boy! If is wasn't for Google people might think you're stupid.
this was sold to the american people back in the day as the information superhighway
you seem to bring behavior worse than at a local diner here online and spew it
Put down the bottle
stop lying
Jack Shit
2020-01-28 23:15:51 UTC
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On Tue, 28 Jan 2020 15:07:19 -0800 (PST), Automatic
Post by Automatic
Post by Jack Shit
On Tue, 28 Jan 2020 14:29:30 -0800 (PST), Automatic
Post by Automatic
Post by Jack Shit
Boy! If is wasn't for Google people might think you're stupid.
this was sold to the american people back in the day as the information superhighway
you seem to bring behavior worse than at a local diner here online and spew it
Put down the bottle
stop lying
stop snipping liar.
Yap Honghor
2020-01-28 09:48:08 UTC
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Post by Automatic
https://news.bloomberglaw.com/health-law-and-business/coronavirus-vaccine-candidate-eyed-for-human-trials-by-april
It won't help you if you contracted the coronavirus because you are a criminal kook, stay away from the park benches
Automatic
2020-01-28 17:44:27 UTC
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Post by Yap Honghor
Post by Automatic
https://news.bloomberglaw.com/health-law-and-business/coronavirus-vaccine-candidate-eyed-for-human-trials-by-april
It won't help you if you contracted the coronavirus
why would you think I have that?
Yap Honghor
2020-01-29 01:48:12 UTC
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Post by Automatic
Post by Yap Honghor
Post by Automatic
https://news.bloomberglaw.com/health-law-and-business/coronavirus-vaccine-candidate-eyed-for-human-trials-by-april
It won't help you if you contracted the coronavirus
why would you think I have that?
Because you are a criminal...
Automatic
2020-01-29 01:54:38 UTC
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Post by Yap Honghor
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Post by Yap Honghor
Post by Automatic
https://news.bloomberglaw.com/health-law-and-business/coronavirus-vaccine-candidate-eyed-for-human-trials-by-april
It won't help you if you contracted the coronavirus
why would you think I have that?
Because you are a criminal...
explain why someone who has been arrested before would be prone to having coronavirus.
explain the logic on that
Yap Honghor
2020-01-29 09:36:29 UTC
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Post by Automatic
Post by Yap Honghor
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Post by Yap Honghor
Post by Automatic
https://news.bloomberglaw.com/health-law-and-business/coronavirus-vaccine-candidate-eyed-for-human-trials-by-april
It won't help you if you contracted the coronavirus
why would you think I have that?
Because you are a criminal...
explain why someone who has been arrested before would be prone to having coronavirus.
explain the logic on that
Explanation: Since bad is always seeking bad, the bad coronavirus will seek criminal like you!!!!!!!!!
Automatic
2020-01-29 16:23:48 UTC
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Post by Yap Honghor
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Post by Yap Honghor
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Post by Yap Honghor
Post by Automatic
https://news.bloomberglaw.com/health-law-and-business/coronavirus-vaccine-candidate-eyed-for-human-trials-by-april
It won't help you if you contracted the coronavirus
why would you think I have that?
Because you are a criminal...
explain why someone who has been arrested before would be prone to having coronavirus.
explain the logic on that
Explanation: Since bad is always seeking bad
so in your mind you concede you are bad, and the alleged [in your mind] me being bad [which you are wrong about] ... heck, you think god is bad for punishing you one day
you certainly are deserving of it
i cant think of anyone more deserving than you

Gronk
2020-01-29 03:28:41 UTC
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A twist of lime.
Siri Cruise
2020-01-29 05:50:12 UTC
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Post by Gronk
A twist of lime.
Aye Aye Yay My Corona.


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:-<> Siri Seal of Disavowal #000-001. Disavowed. Denied. Deleted. @
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The first law of discordiamism: The more energy This post / \
to make order is nore energy made into entropy. insults Islam. Mohammed
Yap Honghor
2020-01-29 09:38:24 UTC
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Post by Siri Cruise
Post by Gronk
A twist of lime.
Aye Aye Yay My Corona.
And I love my Tiger...
Post by Siri Cruise
http://youtu.be/T15WCcV6Fhg
--
'I desire mercy, not sacrifice.' /|\
The first law of discordiamism: The more energy This post / \
to make order is nore energy made into entropy. insults Islam. Mohammed
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